Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

• Main Authors: Fan Yang (Author), Lei Luo (Author), Zhi-De Zhu (Author), Xuan Zhou (Author), Yao Wang (Author), Juan Xue (Author), Juan Zhang (Author), Xin Cai (Author), Zhi-Lin Chen (Author), Qian Ma (Author), Yun-Fei Chen (Author), Yu-Jie Wang (Author), Ying-Ying Luo (Author), Pan Liu (Author), Lei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Chlorogenic acid (CGA) is a phenolic acid that has a wide range of pharmacological effects. However, the protective effects and mechanisms of CGA on liver fibrosis are not clear. This study explored the effects of CGA on miR-21-regulated TGF-β1/Smad7 liver fibrosis in the hepatic stellate LX2...