Targeting SIRT1/FoxO3a/Nrf2 and PI3K/AKT Pathways with Rebamipide Attenuates Acetic Acid-Induced Colitis in Rats

• Main Authors: Maha M. Abdel-Fattah (Author), Emad H. M. Hassanein (Author), Ahmed M. Sayed (Author), Shuruq E. Alsufyani (Author), Azza A. K. El-Sheikh (Author), Hany H. Arab (Author), Wafaa R. Mohamed (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rebamipide is a quinolone derivative that has been commonly used for the treatment of gastric and duodenal ulcers. However, the molecular mechanisms of rebamipide against acetic acid-evoked colitis have not been adequately examined. Hence, the current study aimed to investigate the ameliorative effe...