PESIN Conjugates for Multimodal Imaging: Can Multimerization Compensate Charge Influences on Cell Binding Properties? A Case Study

• Main Authors: Ralph Hübner (Author), Alexa Paretzki (Author), Valeska von Kiedrowski (Author), Marco Maspero (Author), Xia Cheng (Author), Güllü Davarci (Author), Diana Braun (Author), Helen Damerow (Author), Benedikt Judmann (Author), Vasileios Filippou (Author), Clelia Dallanoce (Author), Ralf Schirrmacher (Author), Björn Wängler (Author), Carmen Wängler (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, anionic charges were found to negatively influence the in vitro gastrin-releasing peptide receptor (GRPR) binding parameters of dually radioisotope and fluorescent dye labeled GRPR-specific peptide dimers. From this, the question arose if this adverse impact on in vitro GRP receptor affini...