Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma

• Main Authors: Kevin Liaw (Author), Rajsekhar Reddy (Author), Anjali Sharma (Author), Jiangyu Li (Author), Michelle Chang (Author), Rishi Sharma (Author), Sebastian Salazar (Author), Sujatha Kannan (Author), Rangaramanujam M. Kannan (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Glioblastoma is the most common and aggressive form of primary brain cancer, with median survival of 16-20 months and a 5‐year survival rates of <5%. Recent advances in immunotherapies have shown that addressing the tumor immune profile by targeting the colony‐stimulating factor 1 (CSF‐1...