Tumour‐induced alterations in single‐nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism

• Main Authors: Samet Agca (Author), Aylin Domaniku‐Waraich (Author), Sevval Nur Bilgic (Author), Melis Sucuoglu (Author), Meric Dag (Author), Sukru Anil Dogan (Author), Serkan Kir (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tumour‐induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty. Understand...