Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

• Glavni autori: Yasuhiro Mie (Autor), Yu Hirano (Autor), Keiko Kowata (Autor), Akiyoshi Nakamura (Autor), Mayu Yasunaga (Autor), Yoshihiro Nakajima (Autor), Yasuo Komatsu (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2018-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3' UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs). In this study, we constructed a novel type of AMO flanked by interstrand cross-linked 2&#...