Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes

• Main Authors: Yasuhiro Mie (Author), Yu Hirano (Author), Keiko Kowata (Author), Akiyoshi Nakamura (Author), Mayu Yasunaga (Author), Yoshihiro Nakajima (Author), Yasuo Komatsu (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3' UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs). In this study, we constructed a novel type of AMO flanked by interstrand cross-linked 2&#...