Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity a...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
College of Pharmacy University of Baghdad,
2019-12-01T00:00:00Z.
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| Summary: | Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line. |
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| Item Description: | 2521-3512 1683-3597 10.31351/vol28iss2pp151-158 |