A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, influencing kidney fibrosis. Here, we investigated whether our previously...

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Main Authors: Yi Yang (Author), Milos Mihajlovic (Author), Floris Valentijn (Author), Tri Q. Nguyen (Author), Roel Goldschmeding (Author), Rosalinde Masereeuw (Author)
Format: Book
Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
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