A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

• Egile Nagusiak: Yi Yang (Egilea), Milos Mihajlovic (Egilea), Floris Valentijn (Egilea), Tri Q. Nguyen (Egilea), Roel Goldschmeding (Egilea), Rosalinde Masereeuw (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, influencing kidney fibrosis. Here, we investigated whether our previously...