Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

Simultaneous inhibition of two or more pathways is playing a crucial role in the treatment of hepatocellular carcinoma with complex and diverse pathogenesis. However, there have been no reports of dual-targeting inhibitors for protein kinase membrane-associated tyrosine/threonine 1 (PKMYT1) and hist...

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Main Authors: Yang Yang (Author), Yuting Wang (Author), Jing Chen (Author), Miao-Miao Niu (Author), Yongbin Wang (Author), Xing Jin (Author)
Format: Book
Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
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