Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome

• Main Authors: Johannes Pawlowski (Author), Tatsiana Pukhalskaya (Author), Kelly Cordoro (Author), Marina Kristy Ibraheim (Author), Jeffrey P. North (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Netherton syndrome (NS) is a rare autosomal recessive disorder that occurs due to a loss-of-function mutation in SPINK5; this loss results in significant inflammation, as well as perturbations of the skin barrier's integrity and functionality. While it is unclear which inflammatory pathways con...