Comparison of the efficacy and safety of leflunomide versus placebo combined with basic prednisone therapy in patients with active disease phase of Takayasu arteritis: study protocol for a randomized, double-blinded controlled trial (Takayasu arteritis clinical trial in China: TACTIC)

• Main Authors: Ying Sun (Author), Bingjie Wu (Author), Wei Zhang (Author), Lili Ma (Author), Xiufang Kong (Author), Huiyong Chen (Author), Lindi Jiang (Author)
• Format: Book
• Published: SAGE Publishing, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Takayasu arteritis (TAK) is an immune-induced granulomatous vasculitis that occurs primarily in young Asian women. Our previous cohort studies have indicated that leflunomide (LEF), which can lead to rapid induction and might be a promising alternative treatment for TAK. Objectives: To c...