Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration

• Main Authors: Taras Ardan (Author), Monika Baxa (Author), Božena Levinská (Author), Miroslava Sedláčková (Author), The Duong Nguyen (Author), Jiří Klíma (Author), Štefan Juhás (Author), Jana Juhásová (Author), Petra Šmatlíková (Author), Petra Vochozková (Author), Jan Motlík (Author), Zdenka Ellederová (Author)
• Format: Book
• Published: The Company of Biologists, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently developed therapeutic approaches for the treatment of Huntington's disease (HD) require preclinical testing in large animal models. The minipig is a suitable experimental animal because of its large gyrencephalic brain, body weight of 70-100 kg, long lifespan, and anatomical, physiolog...