Factors Influencing Background Incidence Rate Calculation: Systematic Empirical Evaluation Across an International Network of Observational Databases

• Main Authors: Anna Ostropolets (Author), Xintong Li (Author), Rupa Makadia (Author), Gowtham Rao (Author), Peter R. Rijnbeek (Author), Talita Duarte-Salles (Author), Anthony G. Sena (Author), Azza Shaoibi (Author), Marc A. Suchard (Author), Patrick B. Ryan (Author), Daniel Prieto-Alhambra (Author), George Hripcsak (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Background incidence rates are routinely used in safety studies to evaluate an association of an exposure and outcome. Systematic research on sensitivity of rates to the choice of the study parameters is lacking.Materials and Methods: We used 12 data sources to systematically examine the...