Big data- and machine learning-based analysis of a global pharmacovigilance database enables the discovery of sex-specific differences in the safety profile of dual IL4/IL13 blockade

• Main Authors: Kassem Sharif (Author), Mahmud Omar (Author), Adi Lahat (Author), Yonatan Shneor Patt (Author), Howard Amital (Author), Ghanem Zoabi (Author), Nicola Luigi Bragazzi (Author), Abdulla Watad (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Background: Due to its apparent efficacy and safety, dupilumab, a monoclonal antibody that blocks Interleukin 4 (IL-4) and Interleukin 13 (IL-13), has been approved for treating T-helper 2 (Th2) disorders. However, adverse effects like local injection site reactions, conjunctivitis, headaches, and n...