Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway

• Main Authors: Xue-Ming Zhou (Author), Chen-Yue Liu (Author), Yue-Yun Liu (Author), Qing-Yu Ma (Author), Xin Zhao (Author), You-Ming Jiang (Author), Xiao-Juan Li (Author), Jia-Xu Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: It is revealed that Xiaoyaosan could reduce glutamate level in the hippocampus of depressed rats, whose metabolism leads to the pathophysiology of depression. However, the underlying mechanism remains unclear. This study aims to explore the effect of Xiaoyaosan on glutamate metabolism, and...