Synthesis, in vitro and in vivo evaluation of 11C-O-methylated arylpiperazines as potential serotonin 1A (5-HT1A) receptor antagonist radiotracers

• Main Authors: Vidya Narayanaswami (Author), Junchao Tong (Author), Ferdinando Fiorino (Author), Beatrice Severino (Author), Rosa Sparaco (Author), Elisa Magli (Author), Flavia Giordano (Author), Peter M. Bloomfield (Author), Jaya Prabhakaran (Author), J. John Mann (Author), Neil Vasdev (Author), Kenneth Dahl (Author), J. S. Dileep Kumar (Author)
• Format: Book
• Published: SpringerOpen, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Serotonin 1A (5-HT1A) receptors are implicated in the pathogenesis of several psychiatric and neurodegenerative disorders motivating the development of suitable radiotracers for in vivo positron emission tomography (PET) neuroimaging. The gold standard PET imaging agent for this...