Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

• Main Authors: Munetaka Hirose (Author), Mayumi Takatori (Author), Yoshihiro Kuroda (Author), Mineo Abe (Author), Eri Murata (Author), Tetsuro Isada (Author), Koyo Ueda (Author), Kenji Shigemi (Author), Masayuki Shibazaki (Author), Fumihiro Shimizu (Author), Masashi Hirata (Author), Keita Fukazawa (Author), Masahiro Sakaguchi (Author), Kyoko Kageyama (Author), Yoshifumi Tanaka (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management. To identify a specific inhibitor of TrkA activity, we designed cell-penetrating peptides combined...