Development of [225Ac]Ac-DOTA-C595 as radioimmunotherapy of pancreatic cancer: in vitro evaluation, dosimetric assessment and detector calibration

Development of [225Ac]Ac-DOTA-C595 as radioimmunotherapy of pancreatic cancer: in vitro evaluation, dosimetric assessment and detector calibration

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy which may benefit from radioimmunotherapy. Previously, [177Lu]Lu-DOTA-C595 has been developed as a beta-emitting radioimmunoconjugate to target cancer-specific mucin 1 epitopes (MUC1-CE) overexpressed on PDAC. Ho...

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Main Authors: Ashleigh Hull (Author), William Hsieh (Author), Artem Borysenko (Author), William Tieu (Author), Dylan Bartholomeusz (Author), Eva Bezak (Author)
Format: Book
Published: SpringerOpen, 2023-09-01T00:00:00Z.
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3rd Floor Main Library

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