Development of [225Ac]Ac-DOTA-C595 as radioimmunotherapy of pancreatic cancer: in vitro evaluation, dosimetric assessment and detector calibration

• Κύριοι συγγραφείς: Ashleigh Hull (Συγγραφέας), William Hsieh (Συγγραφέας), Artem Borysenko (Συγγραφέας), William Tieu (Συγγραφέας), Dylan Bartholomeusz (Συγγραφέας), Eva Bezak (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: SpringerOpen, 2023-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy which may benefit from radioimmunotherapy. Previously, [177Lu]Lu-DOTA-C595 has been developed as a beta-emitting radioimmunoconjugate to target cancer-specific mucin 1 epitopes (MUC1-CE) overexpressed on PDAC. Ho...