Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication

• Main Authors: Jose G. Miranda (Author), Wolfgang E. Schleicher (Author), Kristen L. Wells (Author), David G. Ramirez (Author), Samantha P. Landgrave (Author), Richard K.P. Benninger (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+ ([Ca2+]) oscillations, which trigger insulin releas...