Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication
Objective: Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+ ([Ca2+]) oscillations, which trigger insulin releas...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2022-03-01T00:00:00Z.
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