T-588, a Cognitive Enhancer, Protects Against Sodium Nitroprusside-Induced Toxicity in Cultured Astrocytes

• Main Authors: Patamawan Phuagphong (Author), Tetsuo Fukushima (Author), Rie Hatanaka (Author), Kazuhiro Tanaka (Author), Akemichi Baba (Author), Toshio Matsuda (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effects of (1R)-1-benzo[β]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588), a cognitive enhancer, on sodium nitroprusside (SNP)-induced cytotoxicity were examined in cultured rat astrocytes. Treatment with 100 μM SNP for 72 h decreased cell viability and mitochondrial fun...