Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism

• Main Authors: Gabriel Chalhoub (Author), Alina Jamnik (Author), Laura Pajed (Author), Stephanie Kolleritsch (Author), Victoria Hois (Author), Antonia Bagaric (Author), Dominik Prem (Author), Anna Tilp (Author), Dagmar Kolb (Author), Heimo Wolinski (Author), Ulrike Taschler (Author), Thomas Züllig (Author), Gerald N. Rechberger (Author), Claudia Fuchs (Author), Michael Trauner (Author), Gabriele Schoiswohl (Author), Guenter Haemmerle (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hepatic triacylglycerol accumulation and insulin resistance are key features of NAFLD. However, NAFLD development and progression are rather triggered by the aberrant generation of lipid metabolites and signaling molecules including diacylglycerol (DAG) and lysophosphatidylcholine (lysoPC...