PPFIA1-targeting miR-181a mimic and saRNA overcome imatinib resistance in BCR-ABL1-independent chronic myeloid leukemia by suppressing leukemia stem cell regeneration

• Main Authors: Rui Su (Author), Chuting Li (Author), Xiuyuan Wang (Author), Zhendong Li (Author), Ziqi Wen (Author), Zhao Yin (Author), Guiping Huang (Author), Yanjun Liu (Author), Juhua Yang (Author), Haiyan Hu (Author), Hong Nie (Author), Keda Zhang (Author), Jia Fei (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A large proportion of patients with chronic myeloid leukemia (CML; 20%-50%) develop resistance to imatinib in a BCR-ABL1-independent manner. Therefore, new therapeutic strategies for use in this subset of imatinib-resistant CML patients are urgently needed. In this study, we used a multi-omics appro...