Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD

• Main Authors: Juliana Heidler (Author), Athanasios Fysikopoulos (Author), Frank Wempe (Author), Michael Seimetz (Author), Thorsten Bangsow (Author), Ana Tomasovic (Author), Florian Veit (Author), Susan Scheibe (Author), Alexandra Pichl (Author), Friederike Weisel (Author), K. C. Kent Lloyd (Author), Peter Jaksch (Author), Walter Klepetko (Author), Norbert Weissmann (Author), Harald von Melchner (Author)
• Format: Book
• Published: The Company of Biologists, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is caused by chronic exposure to cigarette smoke and/or other environmental pollutants that are believed to induce reactive oxygen species (ROS) that gradually disrupt signalling pathwa...