Ranolazine Attenuates the Enhanced Reverse Na+-Ca2+ Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes

• 主要な著者: Xiao-Jing Wang (著者), Lei-Lei Wang (著者), Chen Fu (著者), Pei-Hua Zhang (著者), Ying Wu (著者), Ji-Hua Ma (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2014-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Ranolazine (RAN), a novel antianginal agent, inhibits the increased late sodium current (INa.L) under many pathological conditions. In this study, the whole-cell patch-clamp technique was used to explore the effects of RAN on INa.L and reverse Na+/Ca2+ exchange current (INCX) in rabbit ventricular m...