Prediction of hERG inhibition of drug discovery compounds using biomimetic HPLC measurements

• Ngā kaituhi matua: Chrysanthos Stergiopoulos (Author), Fotios Tsopelas (Author), Klara Valko (Author)
• Hōputu: Pukapuka
• I whakaputaina: International Association of Physical Chemists (IAPC), 2021-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The major causes of failure of drug discovery compounds in clinics are the lack of efficacy and toxicity. To reduce late-stage failures in the drug discovery process, it is essential to estimate early the probability of adverse effects and potential toxicity. Cardiotoxicity is one of the most often...