Ranking mAb-excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

• Main Authors: Chunting Zhang (Author), Steven T. Gossert (Author), Jonathan Williams (Author), Michael Little (Author), Marilia Barros (Author), Barton Dear (Author), Bradley Falk (Author), Ankit D. Kanthe (Author), Robert Garmise (Author), Luciano Mueller (Author), Andrew Ilott (Author), Anuji Abraham (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTExcipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the mechanis...