Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

• Autori principali: Elizabeth Sara Hecht (Autore), Shrenik Mehta (Autore), Aaron T. Wecksler (Autore), Ben Aguilar (Autore), Nathaniel Swanson (Autore), Wilson Phung (Autore), Ananya Dubey Kelsoe (Autore), W. Henry Benner (Autore), Devin Tesar (Autore), Robert F. Kelley (Autore), Wendy Sandoval (Autore), Alavattam Sreedhara (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to refining downstream processing. It has been hypothesized that...