The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases

• Autores principales: Ammar J. Alsheikh (Autor), Sabrina Wollenhaupt (Autor), Emily A. King (Autor), Jonas Reeb (Autor), Sujana Ghosh (Autor), Lindsay R. Stolzenburg (Autor), Saleh Tamim (Autor), Jozef Lazar (Autor), J. Wade Davis (Autor), Howard J. Jacob (Autor)
• Formato: Libro
• Publicado: BMC, 2022-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background The remarkable growth of genome-wide association studies (GWAS) has created a critical need to experimentally validate the disease-associated variants, 90% of which involve non-coding variants. Methods To determine how the field is addressing this urgent need, we performed a comp...