A glyco-engineering approach for site-specific conjugation to Fab glycans

• Main Authors: Maria L. Jaramillo (Author), Traian Sulea (Author), Yves Durocher (Author), Mauro Acchione (Author), Melissa J. Schur (Author), Anna Robotham (Author), John F. Kelly (Author), Marie-France Goneau (Author), Alma Robert (Author), Yuneivy Cepero-Donates (Author), Michel Gilbert (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTEffective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency while avoiding aggregation or solubility problems...