Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

• Main Authors: Maribel Beaumont (Author), Daniela Tomazela (Author), Douglas Hodges (Author), Grigori Ermakov (Author), Edward Hsieh (Author), Isabel Figueroa (Author), On-Yee So (Author), Yaoli Song (Author), Huiping Ma (Author), Svetlana Antonenko (Author), Wondwessen Mengesha (Author), Yi Wei Zhang (Author), Shuli Zhang (Author), SuChun Hseih (Author), Gulesi Ayanoglu (Author), Xiaoyan Du (Author), Eric Rimmer (Author), Michael Judo (Author), Franklin Vives (Author), Jennifer H. Yearley (Author), Christina Moon (Author), Anthony Manibusan (Author), Nick Knudsen (Author), Andy Beck (Author), Damien Bresson (Author), Dennis Gately (Author), Divas Neupane (Author), Enrique Escandón (Author)
• Format: Book
• Published: SpringerOpen, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properties. Building on these inherent antibody p...