Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

• Main Authors: Loredana Salerno (Author), Luca Vanella (Author), Valeria Sorrenti (Author), Valeria Consoli (Author), Valeria Ciaffaglione (Author), Antonino N. Fallica (Author), Vittorio Canale (Author), Paweł Zajdel (Author), Rosario Pignatello (Author), Sebastiano Intagliata (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, the first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) has been designed, synthesised, and evaluated for its in vitro chemical and enzymatic hydrolysis stability. Predicted in silico physicochemical properties of the newly synthesised hybrid (3) dem...