Deletion of the lipid droplet protein kinase gene affects lipid droplets biogenesis, parasite infectivity, and resistance to trivalent antimony in Leishmania infantum.

Deletion of the lipid droplet protein kinase gene affects lipid droplets biogenesis, parasite infectivity, and resistance to trivalent antimony in Leishmania infantum.

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The Lipid Droplet Protein Kinase (LDK) facilitates lipid droplet (LD) biogenesis, organelles involved in various metabolic and signaling functions in trypanosomatids. As LDK's function has not been previously explored in Leishmania spp., we utilized CRISPR/Cas9 technology to generate LDK-knocko...

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Main Authors: Juliana Martins Ribeiro (Author), Paula Alves Silva (Author), Héllida Marina Costa-Silva (Author), Ana Maria Murta Santi (Author), Silvane Maria Fonseca Murta (Author)
Format: Book
Published: Public Library of Science (PLoS), 2024-01-01T00:00:00Z.
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