Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1

• Main Authors: Shinji Yamamoto (Author), Chiaki Sakemoto (Author), Kensuke Iwasa (Author), Kei Maruyama (Author), Kuniyoshi Shimizu (Author), Keisuke Yoshikawa (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by apoptotic death of mature oligodendrocytes, neuroinflammation, and motor dysfunction. A pentacyclic triterpenoid compound, ursolic acid (UA), has various pharmacological activities, such as anti-inflam...