Synthesis, Biological Evaluation, Molecular Docking and ADME Studies of Novel Pyrrole-Based Schiff Bases as Dual Acting MAO/AChE Inhibitors

• Main Authors: Emilio Mateev (Author), Magdalena Kondeva-Burdina (Author), Maya Georgieva (Author), Alexandrina Mateeva (Author), Iva Valkova (Author), Virginia Tzankova (Author), Alexander Zlatkov (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Considering the complex pathogenesis of Alzheimer's disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target approach. Thus, a series of 13 novel (<b>5e-q</b>) pyrrole-ba...