Activation of Toll-Like Receptor 3 Induces Interleukin-1 Receptor Antagonist Expression by Activating the Interferon Regulatory Factor 3

• Main Authors: Yang Liu (Author), Chun-Fen Mo (Author), Xing-Yan Luo (Author), Hua Li (Author), Hui-Jie Guo (Author), Hai Sun (Author), Song Hu (Author), Li-Mei Li (Author), Yan-Tang Wang (Author), Shu-Xia Yang (Author), Shan Chang (Author), Qiang Zou (Author)
• Format: Book
• Published: Karger Publishers, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toll-like receptor 3 (TLR3) is a sensor of endogenous cell necrosis during the process of acute inflammation. Interleukin (IL)-1 receptor antagonist (IL-1Ra) is an anti-inflammatory cytokine and can negatively regulate the pathogenesis of inflammation. However, whether and how activation of TLR3 can...