Dietary protein defends lean mass and maintains the metabolic benefits of glucagon receptor agonism in mice

• Main Authors: Tatiana Lopes (Author), David CD. Hope (Author), Jose M. Ramos-Pittol (Author), Anna Curtis (Author), Jed V. Shrewsbury (Author), Iona Davies (Author), Zijing Zhou (Author), Alessandro Sardini (Author), James S. Minnion (Author), Dirk Dormann (Author), Gavin A. Bewick (Author), Kevin G. Murphy (Author), David Carling (Author), Stephen R. Bloom (Author), Tricia MM. Tan (Author), Bryn M. Owen (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon has long been proposed as a component of multi-agonist obesity therapeutics due to its ability to induce energy expenditure and cause weight loss. However, chronic glucagon-receptor agonism has been associated with a reduction in circulating amino acids and loss of lean mass. Imp...