HIV-1 Integrase Inhibition Activity by Spiroketals Derived from <i>Plagius flosculosus</i>, an Endemic Plant of Sardinia (Italy) and Corsica (France)

• Main Authors: Cinzia Sanna (Author), Brigida D'Abrosca (Author), Antonio Fiorentino (Author), Federica Giammarino (Author), Ilaria Vicenti (Author), Angela Corona (Author), Alessia Caredda (Author), Enzo Tramontano (Author), Francesca Esposito (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work we investigated, for the first time, the effect of <i>Plagius flosculosus</i> (L.) Alavi & Heywood, a Sardinian-Corsican endemic plant, on HIV-1 integrase (IN) activity. The phytochemical analysis of the leaves chloroform extract led us to isolate and characterize three...