HIV-1 Integrase Inhibition Activity by Spiroketals Derived from <i>Plagius flosculosus</i>, an Endemic Plant of Sardinia (Italy) and Corsica (France)

• Egile Nagusiak: Cinzia Sanna (Egilea), Brigida D'Abrosca (Egilea), Antonio Fiorentino (Egilea), Federica Giammarino (Egilea), Ilaria Vicenti (Egilea), Angela Corona (Egilea), Alessia Caredda (Egilea), Enzo Tramontano (Egilea), Francesca Esposito (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In this work we investigated, for the first time, the effect of <i>Plagius flosculosus</i> (L.) Alavi & Heywood, a Sardinian-Corsican endemic plant, on HIV-1 integrase (IN) activity. The phytochemical analysis of the leaves chloroform extract led us to isolate and characterize three...