Lactoferrin Binding to SARS-CoV-2 Spike Glycoprotein Blocks Pseudoviral Entry and Relieves Iron Protein Dysregulation in Several In Vitro Models

• Main Authors: Antimo Cutone (Author), Luigi Rosa (Author), Maria Carmela Bonaccorsi di Patti (Author), Federico Iacovelli (Author), Maria Pia Conte (Author), Giusi Ianiro (Author), Alice Romeo (Author), Elena Campione (Author), Luca Bianchi (Author), Piera Valenti (Author), Mattia Falconi (Author), Giovanni Musci (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SARS-CoV-2 causes COVID-19, a predominantly pulmonary disease characterized by a burst of pro-inflammatory cytokines and an increase in free iron. The viral glycoprotein Spike mediates fusion to the host cell membrane, but its role as a virulence factor is largely unknown. Recently, the antiviral ac...