Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 polarization and JAK1/STAT3 pathway

• Главные авторы: Renrui Lu (Автор), Li Zhang (Автор), Huihui Wang (Автор), Meng Li (Автор), Weisheng Feng (Автор), Xiaoke Zheng (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Предметы: article
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The present study was performed to investigate the antidepressant effect of echinacoside (ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and lipopolysaccharide (LPS)-stimulated N9 microglial cells. CUMS treatment was performed on C57BL/6 mice for 28 days, followed by gav...