LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma

• Main Authors: Jie Wu (Author), Chunlei Zheng (Author), Yizhe Wang (Author), Zichang Yang (Author), Ce Li (Author), Wanxia Fang (Author), Yue Jin (Author), Kezuo Hou (Author), Yang Cheng (Author), Jianfei Qi (Author), Xiujuan Qu (Author), Yunpeng Liu (Author), Xiaofang Che (Author), Xuejun Hu (Author)
• Format: Book
• Published: BMC, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in the treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, the long non-coding RNAs (lncRNAs) related to EGFR-TKIs resistance and the...