Ring size changes in the development of class I HDAC inhibitors
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7-20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT1...
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Taylor & Francis Group,
2021-01-01T00:00:00Z.
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