Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population

• Main Authors: Aida N. Kawuma (Author), Roeland E. Wasmann (Author), Phumla Sinxadi (Author), Simiso M. Sokhela (Author), Nomathemba Chandiwana (Author), Willem D. F. Venter (Author), Lubbe Wiesner (Author), Gary Maartens (Author), Paolo Denti (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are prodrugs of the nucleotide analogue tenofovir, which acts intracellularly to inhibit HIV replication. Whereas TDF converts to tenofovir in plasma and may cause kidney and bone toxicity, TAF mostly converts to tenofovir...