LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases

• Main Authors: Yanghe Zhang (Author), Qingfei Meng (Author), Qianhui Sun (Author), Zhi-Xiang Xu (Author), Honglan Zhou (Author), Yishu Wang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Live kinase B1 (LKB1) is a tumor suppressor that is mutated in Peutz-Jeghers syndrome (PJS) and a variety of cancers. Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes,...