FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells

• मुख्य लेखकों: Miguel Córdova-Delgado (लेखक), Sebastián Fuentes-Retamal (लेखक), Charlotte Palominos (लेखक), Camila López-Torres (लेखक), Daniela Guzmán-Rivera (लेखक), Oney Ramírez-Rodríguez (लेखक), Ramiro Araya-Maturana (लेखक), Félix A. Urra (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery. FRI-1, methyl 1, 3-dimethyl-5, 8-dioxo-5, 8-dihydro-4-isoquinolinecarboxylate, was previousl...