FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells

• Main Authors: Miguel Córdova-Delgado (Author), Sebastián Fuentes-Retamal (Author), Charlotte Palominos (Author), Camila López-Torres (Author), Daniela Guzmán-Rivera (Author), Oney Ramírez-Rodríguez (Author), Ramiro Araya-Maturana (Author), Félix A. Urra (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery. FRI-1, methyl 1, 3-dimethyl-5, 8-dioxo-5, 8-dihydro-4-isoquinolinecarboxylate, was previousl...