Effect of buffer additives on solubilization and refolding of reteplase inclusion bodies

Reteplase is a non-glycosylated and recombinant form of tissue type plasminogen activator, which is produced in Escherichia coli. However, its overexpression usually leads to formation of inactive aggregates or inclusion bodies. In the present study, we report on the development of optimized process...

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Main Authors: Iman Esmaili (Author), Hamid Mir Mohammad Sadeghi (Author), Vajihe Akbari (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
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3rd Floor Main Library

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