Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

• Autori principali: Manoranjenni eChetty (Autore), Rachel eRose (Autore), Khaled eAbduljalil (Autore), Nikunjkumar ePatel (Autore), Gaohua eLu (Autore), Theresa eCain (Autore), Masoud eJamei (Autore), Amin eRostami-Hodjegan (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

This study aimed to demonstrate the added value of integrating prior in vitro data and knowledge-rich physiologically based pharmacokinetic (PBPK) models with pharmacodynamics (PD) models. Four distinct applications that were developed and tested are presented here. PBPK models were developed for me...