SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

• Main Authors: Xiu Teng (Author), Da-Chao Mou (Author), Hui-Fang Li (Author), Ling Jiao (Author), Sha-Sha Wu (Author), Jin-Kui Pi (Author), Yan Wang (Author), Meng-Li Zhu (Author), Meng Tang (Author), Yi Liu (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Rheumatoid arthritis (RA) is a complex autoimmune disease with multiple etiological factors, among which aberrant memory CD4 T cells activation plays a key role in the initiation and perpetuation of the disease. SIGIRR (single immunoglobulin IL-1R-related receptor), a member of t...