Programmable siRNA pro-drugs that activate RNAi activity in response to specific cellular RNA biomarkers

• Main Authors: Si-ping Han (Author), Lisa Scherer (Author), Matt Gethers (Author), Ane M. Salvador (Author), Marwa Ben Haj Salah (Author), Rebecca Mancusi (Author), Sahil Sagar (Author), Robin Hu (Author), Julia DeRogatis (Author), Ya-Huei Kuo (Author), Guido Marcucci (Author), Saumya Das (Author), John J. Rossi (Author), William A. Goddard, III (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Since Paul Ehrlich's introduction of the "magic bullet" concept in 1908, drug developers have been seeking new ways to target drug activity to diseased cells while limiting effects on normal tissues. In recent years, it has been proposed that coupling riboswitches capable of detecting...